{"id":1805,"date":"2022-10-06T17:35:21","date_gmt":"2022-10-06T08:35:21","guid":{"rendered":"https:\/\/peptistar.com\/?page_id=1805"},"modified":"2025-11-18T14:38:19","modified_gmt":"2025-11-18T05:38:19","slug":"stagps","status":"publish","type":"page","link":"https:\/\/peptistar.com\/en\/technology\/stagps\/","title":{"rendered":"STag-PS Method"},"content":{"rendered":"<div class=\"page-pretitle-blue\">\n<p>Peptide API Manufacturing Technologies<\/p>\n<\/div>\n<h2 class=\"page-title page-title-bottom-short\">STag-PS Method<\/h2>\n<p>\t\tSTag-PS method is the next generation Peptide liquid phase synthesis method with superior economies and environmental friendliness. Since coupling reaction can be efficiently achieved even for low reactivity amino acids, this technology allows significant reduction in the use of amino acid and solvent and can produce high quality Peptides while reducing purification process workload. Additionally, the Peptides obtained with this method allows easy scale-up manufacturing with conventional reactor. Basic manufacturing processes are the same as for SPPS, therefore, equivalence of quality is easily assured and the ability to switchover to the next phase is also a big benefit.<br \/>\n\t\tBy enhancing SEKISUI MEDICAL CO., LTD.\u2019s STag-PS method through joint development efforts, this is an innovative technology specialized for Peptide API manufacturing. PeptiStar is exclusively using the STag-PS method for Peptide API manufacturing.<\/p>\n<div class=\"box-margin-b box-desktop box-gray-border\">\n<h3 class=\"page-heading\">Synthesis Flow of STag-PS Method<\/h3>\n<p>\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/peptistar.com\/wp-content\/uploads\/2022\/10\/technology-stagps1-en.png\" alt=\"Synthesis Flow of STag-PS method\" class=\"alignnone size-full wp-image-1051\" width=\"1861\" height=\"1077\" \/>\n\t\t<\/div>\n<div class=\"box-desktop box-margin-c\">\n<p><strong>Advantages of STag-PS Method<\/strong><\/p>\n<ul class=\"ul-blue-check\">\n<li>Lower raw material usage compared to SPPS<\/li>\n<li>Possible to reduce solvent usage compared to SPPS<\/li>\n<li>Possible to conduct synthesis while monitoring (HPLC)reaction (easier control of impurities)<\/li>\n<li>Possible to conduct continuous coupling in one reactor (One-pot synthesis)<\/li>\n<li>After-process involves only extraction (No need for solidification, filtration or drying)<\/li>\n<\/ul><\/div>\n<div class=\"box-margin-b\">\n<ul class=\"ul-technology-link-2col\">\n<li><a href=\"https:\/\/www.sekisuimedical.jp\/\" rel=\"noopener\" target=\"_blank\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/peptistar.com\/wp-content\/uploads\/2022\/10\/technology-sekisui.png\" alt=\"SEKISUI MEDICAL CO., LTD.\n\" width=\"501\" height=\"429\" class=\"alignnone size-full wp-image-1052\" \/><\/a><span class=\"img-cross\">Joint R&amp;D<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/peptistar.com\/wp-content\/uploads\/2022\/08\/technology-microwave9.png\" alt=\"\" class=\"alignnone size-full wp-image-1043\" width=\"114\" height=\"114\" \/><\/span><\/li>\n<li><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/peptistar.com\/wp-content\/uploads\/2022\/10\/technology-ps.png\" alt=\"PeptiStar Inc.\" width=\"501\" height=\"429\" class=\"alignnone size-full wp-image-1053\" \/><\/li>\n<\/ul>\n<p class=\"text-s text-center-desktop\">* \"STag\" and \"STag-PS\" are registered trademark of SEKISUI MEDICAL CO., LTD. in Japan.<\/p>\n<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Peptide API Manufacturing Technologies STag-PS Method STag-PS method is the next generation Peptide liquid phase synthesis method with superior economies and environmental friendliness. Since coupling reaction can be efficiently achieved even for low reactivity amino acids, this technology allows significant reduction in the use of amino acid and solvent and can produce high quality Peptides while reducing purification process workload. Additionally, the Peptides obtained with this method allows easy scale-up manufacturing with conventional reactor. Basic manufacturing processes are the same as for SPPS, therefore, equivalence of quality is easily assured and the ability to switchover to the next phase is also a big benefit. By enhancing SEKISUI MEDICAL CO., LTD.\u2019s STag-PS method through joint development efforts, this is an innovative technology specialized for Peptide API manufacturing. PeptiStar is exclusively using the STag-PS method for Peptide API manufacturing. Synthesis Flow of STag-PS Method Advantages of STag-PS Method Lower raw material usage compared to SPPS Possible to reduce solvent usage compared to SPPS Possible to conduct synthesis while monitoring (HPLC)reaction (easier control of impurities) Possible to conduct continuous coupling in one reactor (One-pot synthesis) After-process involves only extraction (No need for solidification, filtration or drying) Joint R&amp;D * \"STag\" and \"STag-PS\" are registered trademark of SEKISUI MEDICAL CO., LTD. in Japan.<\/p>\n","protected":false},"author":5,"featured_media":0,"parent":900,"menu_order":47,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_locale":"en_US","_original_post":"https:\/\/peptistar.com\/?page_id=902","footnotes":""},"class_list":["post-1805","page","type-page","status-publish","hentry","en-US"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/peptistar.com\/wp-json\/wp\/v2\/pages\/1805","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/peptistar.com\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/peptistar.com\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/peptistar.com\/wp-json\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"https:\/\/peptistar.com\/wp-json\/wp\/v2\/comments?post=1805"}],"version-history":[{"count":14,"href":"https:\/\/peptistar.com\/wp-json\/wp\/v2\/pages\/1805\/revisions"}],"predecessor-version":[{"id":2930,"href":"https:\/\/peptistar.com\/wp-json\/wp\/v2\/pages\/1805\/revisions\/2930"}],"up":[{"embeddable":true,"href":"https:\/\/peptistar.com\/wp-json\/wp\/v2\/pages\/900"}],"wp:attachment":[{"href":"https:\/\/peptistar.com\/wp-json\/wp\/v2\/media?parent=1805"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}