{"id":1813,"date":"2022-10-06T17:49:45","date_gmt":"2022-10-06T08:49:45","guid":{"rendered":"https:\/\/peptistar.com\/?page_id=1813"},"modified":"2022-10-28T06:52:57","modified_gmt":"2022-10-27T21:52:57","slug":"syncsol","status":"publish","type":"page","link":"https:\/\/peptistar.com\/en\/technology\/syncsol\/","title":{"rendered":"SYNCSOL\u00ae"},"content":{"rendered":"<div class=\"page-pretitle-blue\">\n<p>Peptide API Manufacturing Technologies<\/p>\n<\/div>\n<h2 class=\"page-title page-title-bottom-short\">SYNCSOL\u00ae<\/h2>\n<p>\t\tSYNCSOL\u00ae is a unique Peptide LPPS technology platform that is comprised of R-Coupling\u00ae (Unprotected Amino Acid Coupling Technology) and SIPS\u00ae (New Silyl Group Organic Tagging Technology).<br \/>\n\t\tWhile in a normal SPPS, Fmoc protected amino acid is supported in solid phase and the Fmoc protected amino acid is sequentially elongated from the C-terminal, with R-Coupling\u00ae, amino acid is elongated from the N-terminal with unprotected amino acid. By using amino acid with unprotected group, raw material cost can be significantly reduced and process time can be reduced since deprotection process becomes unnecessary for each condensation. On the other hand, in SIPS\u00ae C-terminal or N-terminal is protected by silyl group that suppresses side reaction and improves physical property at the same time. High quality Peptide intermediates can be obtained by liquid separation or crystallization only.<br \/>\n\t\tBy using the SYNCSOL\u00ae that is comprised of R-Coupling\u00ae and SIPS\u00ae, significant reduction of raw material costs, improved quality of pre-purification Peptides and reduction in purification workload can be realized. This technology was developed through joint development by PeptiDream Inc. and Nissan Chemical corporation, and Peptistar received licensing for this patented technology and plans to actively pursue the application of this technology.<\/p>\n<div class=\"box-margin-b box-desktop box-gray-border\">\n<h3 class=\"page-heading\">R-Coupling\u00ae \uff08Unprotected Amino Acid Coupling Technology\uff09<\/h3>\n<p>\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/peptistar.com\/wp-content\/uploads\/2022\/10\/technology-syncsol1-en.png\" alt=\"R-Coupling\u00ae \uff08Unprotected Amino Acid Coupling Technology\uff09\" class=\"alignnone size-full wp-image-1056\" width=\"1740\" height=\"409\" \/>\n\t\t<\/div>\n<div class=\"box-margin-b box-desktop box-gray-border\">\n<h3 class=\"page-heading\">SIPS\u00ae (New Silyl Group Organic Tagging Technology)<\/h3>\n<p>\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/peptistar.com\/wp-content\/uploads\/2022\/10\/technology-syncsol2-en-1.png\" alt=\"SIPS\u00ae (New Silyl Group Organic Tagging Technology)\" class=\"alignnone size-full wp-image-1057\" width=\"1652\" height=\"758\" \/>\n\t\t<\/div>\n<div class=\"banner-syncsol\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/peptistar.com\/wp-content\/uploads\/2022\/08\/technology-syncsol3.png\" alt=\"SYNCSOL\u2122\" class=\"alignnone size-full wp-image-1058\" width=\"482\" height=\"93\" srcset=\"https:\/\/peptistar.com\/wp-content\/uploads\/2022\/08\/technology-syncsol3.png 482w, https:\/\/peptistar.com\/wp-content\/uploads\/2022\/08\/technology-syncsol3-320x62.png 320w\" sizes=\"auto, (max-width: 482px) 100vw, 482px\" \/><\/div>\n<div class=\"box-margin-c box-desktop\">\n<p><strong>Advantages of SYNCSOL\u00ae<\/strong><\/p>\n<ul class=\"ul-blue-check-2col\">\n<li>Reaction can be achieved under moderate conditions<\/li>\n<li>Cost reduction by eliminating the use of expensive coupling agent<\/li>\n<li>Simpler and amenable to scale-up<\/li>\n<li>Shortening delivery time by eliminating protection\/deprotection processes<\/li>\n<li>Stringent control of epimerization is possible<\/li>\n<li>Can be applied for fragment synthesis<\/li>\n<li>Can be applied to N-Methylated amino acid<\/li>\n<li>Can selectively deprotect tags<\/li>\n<li>Reduce equivalency and unit cost of amino acid<\/li>\n<\/ul><\/div>\n<div class=\"box-margin-b\">\n<ul class=\"ul-technology-link-2col\">\n<li><a href=\"https:\/\/www.nissanchem.co.jp\/eng\/\" rel=\"noopener\" target=\"_blank\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/peptistar.com\/wp-content\/uploads\/2022\/10\/technology-nissanchem.png\" alt=\"Nissan Chemical Corporation\" width=\"501\" height=\"429\" class=\"alignnone size-full wp-image-1059\" \/><\/a><span class=\"img-cross\">Joint R&amp;D<img decoding=\"async\" loading=\"lazy\" src=\"https:\/\/peptistar.com\/wp-content\/uploads\/2022\/08\/technology-microwave9.png\" alt=\"\" class=\"alignnone size-full wp-image-1043\" width=\"114\" height=\"114\"><\/span><\/li>\n<li><a href=\"https:\/\/www.peptidream.com\/\" rel=\"noopener\" target=\"_blank\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/peptistar.com\/wp-content\/uploads\/2022\/10\/technology-pd.png\" alt=\"PeptiDream Inc.\n\" width=\"501\" height=\"429\" class=\"alignnone size-full wp-image-1060\" \/><\/a><\/li>\n<\/ul>\n<p class=\"text-s text-center-desktop\">* SYNCSOL\u3001R-Coupling\u3001SIPS are trademark or registered trademark of Nissan Chemical Corporation.<\/p>\n<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Peptide API Manufacturing Technologies SYNCSOL\u00ae SYNCSOL\u00ae is a unique Peptide LPPS technology platform that is comprised of R-Coupling\u00ae (Unprotected Amino Acid Coupling Technology) and SIPS\u00ae (New Silyl Group Organic Tagging Technology). While in a normal SPPS, Fmoc protected amino acid is supported in solid phase and the Fmoc protected amino acid is sequentially elongated from the C-terminal, with R-Coupling\u00ae, amino acid is elongated from the N-terminal with unprotected amino acid. By using amino acid with unprotected group, raw material cost can be significantly reduced and process time can be reduced since deprotection process becomes unnecessary for each condensation. On the other hand, in SIPS\u00ae C-terminal or N-terminal is protected by silyl group that suppresses side reaction and improves physical property at the same time. High quality Peptide intermediates can be obtained by liquid separation or crystallization only. By using the SYNCSOL\u00ae that is comprised of R-Coupling\u00ae and SIPS\u00ae, significant reduction of raw material costs, improved quality of pre-purification Peptides and reduction in purification workload can be realized. This technology was developed through joint development by PeptiDream Inc. and Nissan Chemical corporation, and Peptistar received licensing for this patented technology and plans to actively pursue the application of this technology. R-Coupling\u00ae \uff08Unprotected Amino Acid Coupling Technology\uff09 SIPS\u00ae (New Silyl Group Organic Tagging Technology) Advantages of SYNCSOL\u00ae Reaction can be achieved under moderate conditions Cost reduction by eliminating the use of expensive coupling agent Simpler and amenable to scale-up Shortening delivery time by eliminating protection\/deprotection processes Stringent control of epimerization is possible Can be applied for fragment synthesis Can be applied to...<\/p>\n","protected":false},"author":5,"featured_media":0,"parent":900,"menu_order":51,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_locale":"en_US","_original_post":"https:\/\/peptistar.com\/?page_id=904","footnotes":""},"class_list":["post-1813","page","type-page","status-publish","hentry","en-US"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/peptistar.com\/wp-json\/wp\/v2\/pages\/1813","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/peptistar.com\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/peptistar.com\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/peptistar.com\/wp-json\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"https:\/\/peptistar.com\/wp-json\/wp\/v2\/comments?post=1813"}],"version-history":[{"count":12,"href":"https:\/\/peptistar.com\/wp-json\/wp\/v2\/pages\/1813\/revisions"}],"predecessor-version":[{"id":2196,"href":"https:\/\/peptistar.com\/wp-json\/wp\/v2\/pages\/1813\/revisions\/2196"}],"up":[{"embeddable":true,"href":"https:\/\/peptistar.com\/wp-json\/wp\/v2\/pages\/900"}],"wp:attachment":[{"href":"https:\/\/peptistar.com\/wp-json\/wp\/v2\/media?parent=1813"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}