Peptide and Oligonucleotide API Manufacturing Technologies
ODS column in reverse-phase HPLC mode is generally used in purification and purity evaluation of Peptides, but a separation method is needed that has high orthogonality to ODS column since there is a possibility of impurity overlapping with the main peak.
To resolve this issue, PeptiStar has jointly developed a separation method that can be used for Peptide API manufacturing. It is now possible to separate impurities that were difficult to separate with conventional methods by using analysis column (DCpak P series) from Daicel Corporation in HILIC or SFC mode that enables separation that has high complementary properties to ODS column. PeptiStar utilizes either ODS column or DCPak P series in order to enable more accurate purity evaluation.
Advantages of HILIC Mode